Esophageal Motility Dysfunction in Children With Rett Syndrome, Gastroesophageal Reflux, and Dysphagia
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چکیده
Background: Rett syndrome is a neurodevelopmental disorder associated with gastroesophageal reflux disease (GERD) and dysphagia. Objective: Correlate esophageal motility disturbances with symptoms of GERD and dysphagia and with MECP2 gene mutations in children with Rett syndrome. Study Design: Thirty-two consecutive Rett patients with a mean (range) age of 6.2 (2.3-14) years with prior history of feeding problems underwent esophageal manometry. Lower esophageal sphincter
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